The Ratio of Activin A and FLRG Allows Prediction of Postoperative Liver Dysfunction in Patients Undergoing Liver Resection

Introduction: Postoperative liver dysfunction (LD) remains a life-threatening complication after resection. With no causal therapy available, research focusing on understanding postoperative regeneration (LR) and the prediction of LD is importance. Here, we evaluate predictive potential for activin A its inhibitory protein FLRG assess their influence development LD. Method: Activin were evaluated in plasma 59 patients undergoing resection using commercially available ELISA kits. Plasma was prepared from blood taken prior to operation (preOP), as well first fifth day (POD). outcome prospectively documented. Results: When evaluating perioperative dynamic FLRG, observed significant decrease both parameters POD1 (p=0.045 p=0.005, respectively). showed an increase POD5 (p=0.004). Interestingly, neither nor different between with without at any timepoint. However, ratio / significantly higher (p=0.037). There FLRG. Conclusions: While circulating dynamics association LD, decreased developing pathophysiology behind these findings still warrants further research, shows possible predictor